Synaptically activated Ca2+ release from internal stores in CNS neurons

William N. Ross, Takeshi Nakamura, Shigeo Watanabe, Matthew Larkum, Nechama Lasser-Ross

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


1. Synaptically activated postsynaptic [Ca2+] i increases occur through three main pathways: Ca2+ entry through voltage-gated Ca2+ channels, Ca2+ entry through ligand-gated channels, and Ca2+ release from internal stores. The first two pathways have been studied intensively; release from stores has been the subject of more recent investigations. 2. Ca2+ release from stores in CNS neurons primarily occurs as a result of IP3 mobilized by activation of metabotropic glutamatergic and/or cholingergic receptors coupled to PLC. Ca2+ release is localized near spines in Purkinje cells and occurs as a wave in the primary apical dendrites of pyramidal cells in the hippocampus and cortex. The amplitude of the [Ca2+]i increase can reach several micromolar, significantly larger than the increase due to backpropagating spikes. 3. The large amplitude, long duration, and unique location of the [Ca2+]i increases due to Ca2+ release from stores suggests that these increases can affect specific downstream signaling mechanisms in neurons.

Original languageEnglish
Pages (from-to)283-295
Number of pages13
JournalCellular and Molecular Neurobiology
Issue number2
Publication statusPublished - 2005 Apr
Externally publishedYes


  • Calcium
  • Dendrite
  • IP
  • Pyramidal neuron

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


Dive into the research topics of 'Synaptically activated Ca2+ release from internal stores in CNS neurons'. Together they form a unique fingerprint.

Cite this