Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity

Tomofumi Kiyokawa; Hironari Hanaoka; Harunobu Iida; Kana Ishimori; Yukiko Takakuwa; Yoshioki Yamasaki; Takahiro Okazaki; Shoichi Ozaki; Kimito Kawahata

doi:10.1080/24725625.2017.1414913

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity

Tomofumi Kiyokawa, Hironari Hanaoka, Harunobu Iida, Kana Ishimori, Yukiko Takakuwa, Yoshioki Yamasaki, Takahiro Okazaki, Shoichi Ozaki, Kimito Kawahata

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by cyclophosphamide (CY) in rheumatology has been rarely described. Most reported cases developed SIADH at the first administration of high-dose CY. We report the case of a 76-year-old female with microscopic polyangiitis (MPA) who developed SIADH during the seventh course of low-dose intravenous cyclophosphamide (IVCY). Our report suggested that SIADH may be developed at any course of IVCY treatment and a process other than CY toxicity may be involved. An exacerbation of interstitial lung disease (ILD) and overexpression of inflammatory cytokines may have contributed to the development of SIADH in this case. Since the active phase of MPA might be a risk factor for SIADH, MPA patients should be evaluated for subclinical SIADH.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Modern Rheumatology Case Reports
Volume	2
Issue number	2
DOIs	https://doi.org/10.1080/24725625.2017.1414913
Publication status	Published - 2018 Jul 3
Externally published	Yes

Keywords

Syndrome of inappropriate antidiuretic hormone secretion
cyclophosphamide
hyponatremia
interstitial lung disease
vasculitis

ASJC Scopus subject areas

Rheumatology

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Kiyokawa, T., Hanaoka, H., Iida, H., Ishimori, K., Takakuwa, Y., Yamasaki, Y., Okazaki, T., Ozaki, S., & Kawahata, K. (2018). Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity. Modern Rheumatology Case Reports, 2(2), 177-180. https://doi.org/10.1080/24725625.2017.1414913

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity. / Kiyokawa, Tomofumi; Hanaoka, Hironari; Iida, Harunobu et al.
In: Modern Rheumatology Case Reports, Vol. 2, No. 2, 03.07.2018, p. 177-180.

Research output: Contribution to journal › Article › peer-review

Kiyokawa, T, Hanaoka, H, Iida, H, Ishimori, K, Takakuwa, Y, Yamasaki, Y, Okazaki, T, Ozaki, S & Kawahata, K 2018, 'Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity', Modern Rheumatology Case Reports, vol. 2, no. 2, pp. 177-180. https://doi.org/10.1080/24725625.2017.1414913

Kiyokawa T, Hanaoka H, Iida H, Ishimori K, Takakuwa Y, Yamasaki Y et al. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity. Modern Rheumatology Case Reports. 2018 Jul 3;2(2):177-180. doi: 10.1080/24725625.2017.1414913

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abstract = "Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by cyclophosphamide (CY) in rheumatology has been rarely described. Most reported cases developed SIADH at the first administration of high-dose CY. We report the case of a 76-year-old female with microscopic polyangiitis (MPA) who developed SIADH during the seventh course of low-dose intravenous cyclophosphamide (IVCY). Our report suggested that SIADH may be developed at any course of IVCY treatment and a process other than CY toxicity may be involved. An exacerbation of interstitial lung disease (ILD) and overexpression of inflammatory cytokines may have contributed to the development of SIADH in this case. Since the active phase of MPA might be a risk factor for SIADH, MPA patients should be evaluated for subclinical SIADH.",

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AU - Takakuwa, Yukiko

AU - Yamasaki, Yoshioki

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AB - Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by cyclophosphamide (CY) in rheumatology has been rarely described. Most reported cases developed SIADH at the first administration of high-dose CY. We report the case of a 76-year-old female with microscopic polyangiitis (MPA) who developed SIADH during the seventh course of low-dose intravenous cyclophosphamide (IVCY). Our report suggested that SIADH may be developed at any course of IVCY treatment and a process other than CY toxicity may be involved. An exacerbation of interstitial lung disease (ILD) and overexpression of inflammatory cytokines may have contributed to the development of SIADH in this case. Since the active phase of MPA might be a risk factor for SIADH, MPA patients should be evaluated for subclinical SIADH.

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Syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with microscopic polyangiitis following low-dose intravenous cyclophosphamide: a possible pathogenic link with disease activity

Abstract

Keywords

ASJC Scopus subject areas

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