TY - JOUR
T1 - Synergistic antitumor activity of mitomycin C and cisplatin against gastric cancer cells in vitro
AU - Saikawa, Yoshiro
AU - Kubota, Tetsuro
AU - Kuo, Tsong‐Hong ‐H
AU - Kase, Suguru
AU - Furukawa, Toshiharu
AU - Tanino, Hirokazu
AU - Ishibiki, Kyuya
AU - Kitajima, Masaki
PY - 1993/10
Y1 - 1993/10
N2 - The synergistic antitumor activity of mitomycin C (MMC) and cisplatin (DDP) against the gastric cancer cell lines MKN‐28 and MKN‐45 was assessed in vitro using the MTT assay. The synergism of the two agents was evaluated in terms of the interaction index (I.I.). The sequence of MMC followed by DDP showed higher antitumor activity than the reverse sequence against MKN‐28 and MKN‐45, and the intracellular concentration of platinum was significantly increased in MKN‐45 by preincubation with MMC, suggesting that MMC modulates cellular permeability to DDP or the ability of DDP to intercalate DNA. Since these two antitumor agents show different types of toxicity clinically, i.e., myelotoxicity by MMC and nephrotoxicity by DDP, this combination chemotherapy could be advantageous by providing synergistic antitumor activity without increased toxicity. © 1993 Wiley‐Liss, Inc.
AB - The synergistic antitumor activity of mitomycin C (MMC) and cisplatin (DDP) against the gastric cancer cell lines MKN‐28 and MKN‐45 was assessed in vitro using the MTT assay. The synergism of the two agents was evaluated in terms of the interaction index (I.I.). The sequence of MMC followed by DDP showed higher antitumor activity than the reverse sequence against MKN‐28 and MKN‐45, and the intracellular concentration of platinum was significantly increased in MKN‐45 by preincubation with MMC, suggesting that MMC modulates cellular permeability to DDP or the ability of DDP to intercalate DNA. Since these two antitumor agents show different types of toxicity clinically, i.e., myelotoxicity by MMC and nephrotoxicity by DDP, this combination chemotherapy could be advantageous by providing synergistic antitumor activity without increased toxicity. © 1993 Wiley‐Liss, Inc.
KW - biochemical modulation
KW - combination chemotherapy
KW - gastric cancer
UR - http://www.scopus.com/inward/record.url?scp=0027448944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027448944&partnerID=8YFLogxK
U2 - 10.1002/jso.2930540209
DO - 10.1002/jso.2930540209
M3 - Article
C2 - 8412167
AN - SCOPUS:0027448944
SN - 0022-4790
VL - 54
SP - 98
EP - 102
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -
