TY - JOUR
T1 - Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
AU - Yamamoto, Kazuki
AU - Sato, Toyotaka
AU - Hikiji, Yuta
AU - Katsuyama, Akira
AU - Matsumaru, Takanori
AU - Yakushiji, Fumika
AU - Yokota, Shin Ichi
AU - Ichikawa, Satoshi
N1 - Funding Information:
This research was supported in part by JSPS Grant-in-Aid for Scientific Research (B) (Grant Number 16H05097 to S.I.), Grant-in Aid for Scientific Research on Innovative Areas ?Frontier Research on Chemical Communications? (No 18H04599 to S.I.), Takeda Foundation, The Tokyo Biomedical Research Foundation and was partly supported by Hokkaido University, Global Facility Center (GFC), Pharma Science Open Unit (PSOU), funded by MEXT under ?Support Program for Implementation of New Equipment Sharing System?, the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research; BINDS) from the Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2020/2/20
Y1 - 2020/2/20
N2 - Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.
AB - Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.
KW - antibacterial
KW - nucleoside natural products
KW - organic chemistry
UR - http://www.scopus.com/inward/record.url?scp=85073926503&partnerID=8YFLogxK
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U2 - 10.1080/15257770.2019.1649696
DO - 10.1080/15257770.2019.1649696
M3 - Article
C2 - 31566068
AN - SCOPUS:85073926503
SN - 1525-7770
VL - 39
SP - 349
EP - 364
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 1-3
ER -