Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

Naoyuki Nishikawa, Hiroyuki Komazawa, Atsushi Orikasa, Mitsuo Yoshikane, Jiro Yamaguchi, Masayoshi Kojima, Mitsunori Ono, Isamu Itoh, Ichiro Azuma, Hideki Fujii, Jun Murata, Ikuo Saiki

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

Original languageEnglish
Pages (from-to)2725-2728
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number22
DOIs
Publication statusPublished - 1996 Nov 19
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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