Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature

Midori A. Arai; Yujiro Uchino; Shuwa Hanazawa; Xiaofan Li; Naoki Kimura; Masami Ishibashi

doi:10.3987/COM-08-S(N)108

Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature

Midori A. Arai, Yujiro Uchino, Shuwa Hanazawa, Xiaofan Li, Naoki Kimura, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.

Original language	English
Pages (from-to)	1425-1438
Number of pages	14
Journal	Heterocycles
Volume	76
Issue number	2
DOIs	https://doi.org/10.3987/COM-08-S(N)108
Publication status	Published - 2008 Nov 1
Externally published	Yes

Keywords

Inhibitor
Myxomycete
Peptide
Stereoisomer
Wnt Signal

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-08-S(N)108

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abstract = "Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.",

keywords = "Inhibitor, Myxomycete, Peptide, Stereoisomer, Wnt Signal",

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T1 - Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature

AU - Arai, Midori A.

AU - Uchino, Yujiro

AU - Hanazawa, Shuwa

AU - Li, Xiaofan

AU - Kimura, Naoki

AU - Ishibashi, Masami

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.

AB - Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.

KW - Inhibitor

KW - Myxomycete

KW - Peptide

KW - Stereoisomer

KW - Wnt Signal

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Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature

Abstract

Keywords

ASJC Scopus subject areas

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