Synthesis and properties of novel gels based on cyclic acetal

Sachiko Kaihara; Parth Modi; Jennifer Curcio; Kazunobu Toshima; John Fisher; Shuichi Matsumura

Synthesis and properties of novel gels based on cyclic acetal

Sachiko Kaihara
, Parth Modi
, Jennifer Curcio
, Kazunobu Toshima
, John Fisher
, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to conference › Paper › peer-review

Abstract

A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using ¹H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.

Original language	English
Pages	5406-5407
Number of pages	2
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sept 20 → 2006 Sept 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	06/9/20 → 06/9/22

Keywords

Biomaterial
Cyclic aetal
Gel

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Synthesis and properties of novel gels based on cyclic acetal",

abstract = "A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using 1H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.",

keywords = "Biomaterial, Cyclic aetal, Gel",

author = "Sachiko Kaihara and Parth Modi and Jennifer Curcio and Kazunobu Toshima and John Fisher and Shuichi Matsumura",

year = "2006",

language = "English",

pages = "5406--5407",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - Synthesis and properties of novel gels based on cyclic acetal

AU - Kaihara, Sachiko

AU - Modi, Parth

AU - Curcio, Jennifer

AU - Toshima, Kazunobu

AU - Fisher, John

AU - Matsumura, Shuichi

PY - 2006

Y1 - 2006

N2 - A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using 1H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.

AB - A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using 1H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.

KW - Biomaterial

KW - Cyclic aetal

KW - Gel

UR - https://www.scopus.com/pages/publications/33846127158

UR - https://www.scopus.com/pages/publications/33846127158#tab=citedBy

M3 - Paper

AN - SCOPUS:33846127158

SP - 5406

EP - 5407

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Synthesis and properties of novel gels based on cyclic acetal

Abstract

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Keywords

ASJC Scopus subject areas

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