Synthesis of high molecular weight polythioester using an enzyme

Makoto Kato, Kazunobu Toshima, Shuichi Matsumura

Research output: Contribution to conferencePaperpeer-review


Polythioesters have recently been attracted attention due to their interesting characteristics, such as poor solubility against organic solvents and higher heat stability compared to polyoxyesters. Polythioesters were synthesized by the direct polycondensation of 1,6-hexanedithiol and diacid diesters having a variety of methylene lengths using lipase CAas a catalyst. The obtained polythioesters showed a higher melting temperature compared to those of the corresponding polyoxyesters. The 1,6-hexanedithiol and diacid diesters were reacted in n-nonane using lipase CA to produce cyclic oligomers with an Mw of a few hundreds. Synthesis of polythioester was studied using these cyclic oligomers. A high-molecular weight polythioester having an M w of about 120,000 was produced through the ring-opening polymerization using lipase CA.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26


Other55th SPSJ Annual Meeting


  • Biodegradation
  • Cyclic oligomers
  • Enzymatic polymerization
  • Polythioester
  • Ring opening polymerization

ASJC Scopus subject areas

  • Engineering(all)


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