Synthesis of methylophiopogonanone a

Ryo Katagiri, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
Issue number5
Publication statusPublished - 2020

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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