Synthesis of neutral glycosphingolipids from Zygomycetes

Noriyasu Hada, Junko Oka, Kyoko Hakamata, Kenji Yamamoto, Tadahiro Takeda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Novel neutral glycosphingolipids (NGSLs) containing Gal-α1→6Gal, previously found in the Zygomycetes species Mucor hiemalis, were synthesized. The structures of these compounds are different from those of other fungal GSLs, and they are expected to be involved in host-parasite interactions. A key step in their synthesis is direct 1,2-cis α-selective galactosylation of 4,6-diol tri- and tetrasaccharide acceptors with a galactosyl donor in the presence of N-iodosuccinimide (NIS)/trifluoromethanesulfonic acid (TfOH). The fully protected glycosides were deprotected to give the two target glycosphingolipids.

Original languageEnglish
Pages (from-to)2315-2324
Number of pages10
JournalCarbohydrate Research
Issue number13
Publication statusPublished - 2008 Sept 8
Externally publishedYes


  • 1,2-cis-Glycoside
  • Di-tert-butylsilylene group
  • Mucor hiemalis
  • Zygomycetes species
  • α-Galactosylation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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