Synthesis of Thermoplastic Poly(2-methoxyethyl acrylate)-Based Polyurethane by RAFT and Condensation Polymerization

Shunsuke Tazawa; Tomoki Maeda; Masamitsu Nakayama; Atsushi Hotta

doi:10.1002/marc.202000346

Synthesis of Thermoplastic Poly(2-methoxyethyl acrylate)-Based Polyurethane by RAFT and Condensation Polymerization

Shunsuke Tazawa, Tomoki Maeda, Masamitsu Nakayama, Atsushi Hotta

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Thermoplastic solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl-terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA-based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA-based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA-based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond-like carbon (F-DLC), a well-known highly antithrombogenic material. It is concluded that a newly synthesized PMEA-based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.

Original language	English
Article number	2000346
Journal	Macromolecular Rapid Communications
Volume	41
Issue number	19
DOIs	https://doi.org/10.1002/marc.202000346
Publication status	Published - 2020 Oct 1

Keywords

PMEA
antithrombogenicity
hydrogen bonding
polymerizations
thermoplastics

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/marc.202000346

Cite this

@article{74be5552b778404ea5336a95f1699636,

title = "Synthesis of Thermoplastic Poly(2-methoxyethyl acrylate)-Based Polyurethane by RAFT and Condensation Polymerization",

abstract = "Thermoplastic solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl-terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA-based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA-based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA-based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond-like carbon (F-DLC), a well-known highly antithrombogenic material. It is concluded that a newly synthesized PMEA-based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.",

keywords = "PMEA, antithrombogenicity, hydrogen bonding, polymerizations, thermoplastics",

author = "Shunsuke Tazawa and Tomoki Maeda and Masamitsu Nakayama and Atsushi Hotta",

note = "Funding Information: This work was supported in part by Grant‐in‐Aid for Scientific Research (A) (No. 19H00831 to A.H.) from Japan Society for the Promotion of Science and in part by Grant‐in‐Aid for Challenging Exploratory Research (No. 19K22067 to A.H.) from Japan Society for the Promotion of Science, and in part by Grant‐in‐Aid for JSPS Fellows (No. 19J12154 to S.T.) from the Japan Society for the Promotion of Science (JSPS: “KAKENHI”). The DMA measurements were performed at TA Instruments, Japan, and the platelet adhesion tests were conducted at Tokai university, Japan. The authors appreciate Prof. Dr. Terumitsu Hasebe for the platelet adhesion test. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

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doi = "10.1002/marc.202000346",

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AU - Tazawa, Shunsuke

AU - Maeda, Tomoki

AU - Nakayama, Masamitsu

AU - Hotta, Atsushi

N1 - Funding Information: This work was supported in part by Grant‐in‐Aid for Scientific Research (A) (No. 19H00831 to A.H.) from Japan Society for the Promotion of Science and in part by Grant‐in‐Aid for Challenging Exploratory Research (No. 19K22067 to A.H.) from Japan Society for the Promotion of Science, and in part by Grant‐in‐Aid for JSPS Fellows (No. 19J12154 to S.T.) from the Japan Society for the Promotion of Science (JSPS: “KAKENHI”). The DMA measurements were performed at TA Instruments, Japan, and the platelet adhesion tests were conducted at Tokai university, Japan. The authors appreciate Prof. Dr. Terumitsu Hasebe for the platelet adhesion test. Publisher Copyright: © 2020 Wiley-VCH GmbH

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Thermoplastic solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl-terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA-based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA-based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA-based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond-like carbon (F-DLC), a well-known highly antithrombogenic material. It is concluded that a newly synthesized PMEA-based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.

AB - Thermoplastic solid poly(2-methoxyethyl acrylate) (PMEA)-based polyurethane (PU) is synthesized through the reversible addition−fragmentation chain transfer (RAFT) polymerization and the condensation polymerization, using hydroxyl-terminated RAFT reagents and diisocyanate, respectively. Neat PMEA is a promising antithrombogenic liquid used in the medical fields. The thermoplastic property of the solid PMEA-based PU due to hydrogen bonding is confirmed by the dynamic mechanical analysis (DMA) at temperature below 72 °C. The antithrombogenic property of PMEA-based PU is also analyzed by the platelet adhesion test. The number of platelets on PMEA-based PU is 17 cells per unit area, which is smaller than that on the fluorinated diamond-like carbon (F-DLC), a well-known highly antithrombogenic material. It is concluded that a newly synthesized PMEA-based PU exhibits thermoplastic characteristics with excellent antithrombogenicity.

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Synthesis of Thermoplastic Poly(2-methoxyethyl acrylate)-Based Polyurethane by RAFT and Condensation Polymerization

Abstract

Keywords

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