Synthesis of Two Macrocyclic Fragments of Manadomanzamine Alkaloids

Yuki Kurihara, Atsushi Azuma, Haruka Yasufuku, Shinsaku Takikawa, Noritaka Chida, Takaaki Sato

Research output: Contribution to journalArticlepeer-review


The synthesis of two macrocyclic fragments in the manadomanzamine alkaloids based on a strategy using reductive nucleophilic addition to macrolactams is reported. The sequence through the Wittig coupling and macrolactamization gives quick access to both eleven-membered and ten-membered macrolactams. The iridium-catalyzed reductive Strecker reaction of the ten-membered macrolactam takes place via the corresponding unstable imine intermediate.

Original languageEnglish
Pages (from-to)1146-1149
Number of pages4
JournalChemistry Letters
Issue number12
Publication statusPublished - 2022 Dec


  • Amide
  • Manzamine alkaloid
  • Total synthesis

ASJC Scopus subject areas

  • Chemistry(all)


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