Synthetic bioluminescent coelenterazine derivatives

Ryo Nishihara, Daniel Citterio, Koji Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages13
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Bioluminescence
  • Chemiluminescence
  • Coelenterazine (CTZ)
  • DeepBlueC
  • Luciferase
  • Luciferin
  • Renilla luciferase (RLuc)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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