Synthetic carbohydrate research based on organic electrochemistry

Toshiki Nokami, Kodai Saito, Jun Ichi Yoshida

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)


Development of a novel method for generating glycosyl cations or their equivalents is highly desired, because such intermediates are crucial for developing stereoselective glycosylations in oligosaccharide syntheses. In this review we focus on electrochemical methods that we have recently developed. The anodic oxidation of thioglycosides is effective for generating glycosyl triflate pools, which react with glycosyl acceptors. The reaction of glycosyl triflate pools with diorganosulfides gives glycosyl sulfonium ions, which also serve as effective glycosylation intermediates. The indirect electrochemical method is effective for the generation of glycosyl cations or their equivalents and the use of a flow-microreactor system enables glycosylation using such intermediates.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCarbohydrate Research
Publication statusPublished - 2012 Dec 1
Externally publishedYes


  • Anodic oxidation
  • Glycosyl triflate
  • Glycosylation
  • Oligosaccharide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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