TY - JOUR
T1 - Synthetic studies of erythromycin derivatives syntheses and antimicrobial activities of 3”-Epi-erythromycin A and (9S) 11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A
AU - Nakata, Masaya
AU - Tamai, Tetsuro
AU - Miura, Yukiko
AU - Kinoshita, Mitsuhiro
AU - Tatsuta, Kuniaki
PY - 1993/5
Y1 - 1993/5
N2 - Two new derivatives, 3”-epi-erythromycin A (2) and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A (3), have been synthesized by using glycosylation with glycal (Ferrier rearrangement), bromomethoxylation and bis(tributyltin) oxide-bromine oxidation as the key steps. Their antimicrobial activities were compared with those of erythromycin A (1).
AB - Two new derivatives, 3”-epi-erythromycin A (2) and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11-oxoerythromycin A (3), have been synthesized by using glycosylation with glycal (Ferrier rearrangement), bromomethoxylation and bis(tributyltin) oxide-bromine oxidation as the key steps. Their antimicrobial activities were compared with those of erythromycin A (1).
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U2 - 10.7164/antibiotics.46.813
DO - 10.7164/antibiotics.46.813
M3 - Article
C2 - 8514636
AN - SCOPUS:0027270015
SN - 0021-8820
VL - 46
SP - 813
EP - 826
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 5
ER -