Synthetic studies on altohyrtins (spongistatins): Synthesis of the C29-C44 (EF) portion

Takeshi Terauchi, Masataka Morita, Kyoko Kimijima, Yasuhiro Nakamura, Gouichirou Hayashi, Taisaku Tanaka, Naoki Kanoh, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The C29-C44 portion of altohyrtins (spongistatins) has been prepared from 1,5-pentanediol and D-glucose in a stereoselective manner. The convergent synthesis relied on a coupling reaction of the C29-C37 vinyl bromide and the C38-C44 Weinreb amide, diastereoselective reduction of the C38 ketone, and stereoselective formation of the C33-C37 (E ring) acetal.

Original languageEnglish
Pages (from-to)5505-5508
Number of pages4
JournalTetrahedron Letters
Issue number32
Publication statusPublished - 2001 Aug 6


  • Altohyrtins
  • Spongistatins
  • Stereoselective synthesis
  • Weinreb coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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