Synthetic studies on apoptolidin: Synthesis of the C1-C21 macrolide fragment

Kazunobu Toshima; Tsuyoshi Arita; Koji Kato; Daisuke Tanaka; Shuichi Matsumura

doi:10.1016/S0040-4039(01)01948-7

Synthetic studies on apoptolidin: Synthesis of the C1-C21 macrolide fragment

Kazunobu Toshima, Tsuyoshi Arita, Koji Kato, Daisuke Tanaka, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.

Original language	English
Pages (from-to)	8873-8876
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(01)01948-7
Publication status	Published - 2001 Dec 10

Keywords

Apoptolidin
Apoptosis
Macrocyclization
Macrolide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01948-7

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title = "Synthetic studies on apoptolidin: Synthesis of the C1-C21 macrolide fragment",

abstract = "The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.",

keywords = "Apoptolidin, Apoptosis, Macrocyclization, Macrolide",

author = "Kazunobu Toshima and Tsuyoshi Arita and Koji Kato and Daisuke Tanaka and Shuichi Matsumura",

year = "2001",

month = dec,

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doi = "10.1016/S0040-4039(01)01948-7",

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journal = "Tetrahedron Letters",

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T1 - Synthetic studies on apoptolidin

T2 - Synthesis of the C1-C21 macrolide fragment

AU - Toshima, Kazunobu

AU - Arita, Tsuyoshi

AU - Kato, Koji

AU - Tanaka, Daisuke

AU - Matsumura, Shuichi

PY - 2001/12/10

Y1 - 2001/12/10

N2 - The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.

AB - The stereoselective and convergent synthesis of the C1-C21 macrocyclic segment (2) of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described.

KW - Apoptolidin

KW - Apoptosis

KW - Macrocyclization

KW - Macrolide

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U2 - 10.1016/S0040-4039(01)01948-7

DO - 10.1016/S0040-4039(01)01948-7

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SN - 0040-4039

VL - 42

SP - 8873

EP - 8876

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Synthetic studies on apoptolidin: Synthesis of the C1-C21 macrolide fragment

Abstract

Keywords

ASJC Scopus subject areas

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