TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction

Hiroshi Shibuya; Kyoko Yamaguchi; Kyoko Shirakabe; Akane Tonegawa; Yukiko Gotoh; Naoto Ueno; Kenji Irie; Eisuke Nishida; Kunihiro Matsumoto

doi:10.1126/science.272.5265.1179

TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction

Hiroshi Shibuya, Kyoko Yamaguchi, Kyoko Shirakabe, Akane Tonegawa, Yukiko Gotoh, Naoto Ueno, Kenji Irie, Eisuke Nishida, Kunihiro Matsumoto

Research output: Contribution to journal › Article › peer-review

529 Citations (Scopus)

Abstract

Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-β superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-β signal transduction.

Original language	English
Pages (from-to)	1179-1182
Number of pages	4
Journal	Science
Volume	272
Issue number	5265
DOIs	https://doi.org/10.1126/science.272.5265.1179
Publication status	Published - 1996 May 24
Externally published	Yes

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title = "TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction",

abstract = "Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-β superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-β signal transduction.",

author = "Hiroshi Shibuya and Kyoko Yamaguchi and Kyoko Shirakabe and Akane Tonegawa and Yukiko Gotoh and Naoto Ueno and Kenji Irie and Eisuke Nishida and Kunihiro Matsumoto",

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doi = "10.1126/science.272.5265.1179",

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T2 - An activator of the TAK1 MAPKKK in TGF-β signal transduction

AU - Shibuya, Hiroshi

AU - Yamaguchi, Kyoko

AU - Shirakabe, Kyoko

AU - Tonegawa, Akane

AU - Gotoh, Yukiko

AU - Ueno, Naoto

AU - Irie, Kenji

AU - Nishida, Eisuke

AU - Matsumoto, Kunihiro

PY - 1996/5/24

Y1 - 1996/5/24

N2 - Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-β superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-β signal transduction.

AB - Transforming growth factor-β (TGF-β) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-β superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-β signal transduction.

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TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction

Abstract

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