Tandem autologous versus autologous/allogeneic transplantation for multiple myeloma: propensity score analysis

Koji Kawamura, Takashi Ikeda, Shotaro Hagiwara, Takehiko Mori, Atsushi Shinagawa, Kaichi Nishiwaki, Kazuteru Ohashi, Shiro Kubonishi, Takahiro Fukuda, Toshiro Ito, Naoto Tomita, Tatsuo Ichinohe, Koji Kato, Yasuo Morishima, Yoshiko Atsuta, Kazutaka Sunami, Yoshinobu Kanda

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Abstract: Autologous hematopoietic stem cell transplantation (auto-HCT) is considered a standard therapy for transplant-eligible patients with multiple myeloma, while allogeneic HCT (allo-HCT) is controversial. We retrospectively analyzed 765 patients with myeloma who underwent tandem transplantation between 1998 and 2012 using Japanese registry data. We evaluated the clinical outcomes of tandem auto-HCT (n = 676) and auto/allo-HCT (n = 89). To adjust for a selection bias, we compared overall survival (OS) between the two groups by a propensity score analysis. The probability of OS at six years was 58.5% for the tandem auto-HCT group and 54.4% for the tandem auto/allo-HCT group (p = 0.47). In a matched-pair analysis based on the propensity score, the difference in survival between the two groups was not statistically significant, although the survival curve appeared to reach a plateau beyond five years in the auto/allo group. Further strategies to reduce treatment-related mortality and enhance a graft-versus-myeloma effect are necessary to improve OS.

Original languageEnglish
Pages (from-to)2077-2083
Number of pages7
JournalLeukemia and Lymphoma
Issue number9
Publication statusPublished - 2016 Sept 1


  • Allogeneic transplantation
  • multiple myeloma
  • novel agents
  • propensity score analysis
  • tandem autologous transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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