TY - JOUR
T1 - Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis
T2 - A Japanese nationwide randomized controlled trial
AU - Watanabe, Toshiaki
AU - Ajioka, Yoichi
AU - Matsumoto, Takayuki
AU - Tomotsugu, Naoki
AU - Takebayashi, Toru
AU - Inoue, Eisuke
AU - Iizuka, Bunei
AU - Igarashi, Masahiro
AU - Iwao, Yasushi
AU - Ohtsuka, Kazuo
AU - Kudo, Shin Ei
AU - Kobayashi, Kiyonori
AU - Sada, Miwa
AU - Matsumoto, Takayuki
AU - Hirata, Ichiro
AU - Murakami, Kazunari
AU - Nagahori, Masakazu
AU - Watanabe, Kenji
AU - Hida, Nobuyuki
AU - Ueno, Fumiaki
AU - Tanaka, Shinji
AU - Watanabe, Mamoru
AU - Hibi, Toshifumi
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and by Labour Sciences Research Grants for Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan.
PY - 2011/1
Y1 - 2011/1
N2 - Colorectal cancer is one of the complications of ulcerative colitis (UC) and the risk of cancer increases as the duration of the disease becomes longer. Surveillance colonoscopy has been considered to be important for the early detection and early treatment of colorectal cancer, especially in longstanding UC. Because it is not always easy to detect neoplastic lesions in UC endoscopically, guidelines recommend the use of step biopsy in surveillance, in which either 4 biopsy specimens for every 10 cm or a total of 33 or more biopsy specimens are obtained. However, it has been pointed out that a step biopsy obtaining several tens of biopsy specimens may not be an ideal method in terms of invasiveness to the patient or medical cost. Instead of step biopsy, recent studies report the usefulness of target biopsy, in which biopsy tissues are obtained only from regions suspected of neoplasia. Therefore, the Research Group for Intractable Inflammatory Bowel Disease of the Ministry of Health, Labour and Welfare of Japan has initiated a randomized controlled study to compare the efficacy of step biopsy and target biopsy. The present article gives an introduction to this ongoing randomized controlled trial in Japan.
AB - Colorectal cancer is one of the complications of ulcerative colitis (UC) and the risk of cancer increases as the duration of the disease becomes longer. Surveillance colonoscopy has been considered to be important for the early detection and early treatment of colorectal cancer, especially in longstanding UC. Because it is not always easy to detect neoplastic lesions in UC endoscopically, guidelines recommend the use of step biopsy in surveillance, in which either 4 biopsy specimens for every 10 cm or a total of 33 or more biopsy specimens are obtained. However, it has been pointed out that a step biopsy obtaining several tens of biopsy specimens may not be an ideal method in terms of invasiveness to the patient or medical cost. Instead of step biopsy, recent studies report the usefulness of target biopsy, in which biopsy tissues are obtained only from regions suspected of neoplasia. Therefore, the Research Group for Intractable Inflammatory Bowel Disease of the Ministry of Health, Labour and Welfare of Japan has initiated a randomized controlled study to compare the efficacy of step biopsy and target biopsy. The present article gives an introduction to this ongoing randomized controlled trial in Japan.
KW - Colonoscopy
KW - Colorectal cancer
KW - Dysplasia
KW - Randomized controlled trial
KW - Ulcerative colitis
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U2 - 10.1007/s00535-010-0327-0
DO - 10.1007/s00535-010-0327-0
M3 - Article
C2 - 21038106
AN - SCOPUS:78651376542
SN - 0944-1174
VL - 46
SP - 11
EP - 16
JO - Journal of gastroenterology
JF - Journal of gastroenterology
IS - SUPPL. 1
ER -
