Target protein-oriented isolations for bioactive natural products

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Natural products are very attractive for development of medicine. Their structure and bioactivities are often beyond human knowledge and imagination. We have developed isolation methods for target protein-oriented natural products so as quickly to discover bioactive compounds from natural resources. This review summarizes our recent results including protein beads methods for neural stem cells differentiation activators and new cancer drug candidates. Syntheses of isolated compounds are described. We also developed protein plate method for identification of protein-protein interaction inhibitors. Because protein binding ability is tightly related to bioactivity, protein-based natural products isolation is a powerful means to find new candidate medicines.

Original languageEnglish
Pages (from-to)503-515
Number of pages13
JournalChemical and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - 2021 Jun 1


  • Cancer cell
  • Natural product
  • Neural stem cell
  • Protein bead
  • Protein plate

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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