Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki; Kana Tsumura; Takeo Tsuzuki; Shuichi Matsumura; Kazunobu Toshima

doi:10.1039/b708947c

Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

Original language	English
Pages (from-to)	4260-4262
Number of pages	3
Journal	Chemical Communications
Issue number	41
DOIs	https://doi.org/10.1039/b708947c
Publication status	Published - 2007 Jan 1

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid",

abstract = "A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.",

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AU - Suzuki, Akane

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AU - Tsuzuki, Takeo

AU - Matsumura, Shuichi

AU - Toshima, Kazunobu

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AB - A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

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Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Abstract

ASJC Scopus subject areas

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