Targeting neurovascular interaction in retinal disorders

Zhongjie Fu, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang, Zhongxiao Wang, Chi Hsiu Liu, Steve S. Cho, William Britton, Timothy S. Kern, David A. Antonetti, Ann Hellström, Lois E.H. Smith

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metabolic needs control both normal retinal vascular development and pathological aberrant vascular growth. Particularly, photoreceptors, with the highest density of mitochondria in the body, regulate retinal vascular development by modulating angiogenic and inflammatory factors. Photoreceptor metabolic dysfunction, oxidative stress, and inflammation may cause adaptive but ultimately pathological retinal vascular responses, leading to blindness. Here we focus on the factors involved in neurovascular interactions, which are potential therapeutic targets to decrease energy demand and/or to increase energy production for neovascular retinal disorders.

Original languageEnglish
Article number1503
JournalInternational journal of molecular sciences
Issue number4
Publication statusPublished - 2020 Feb 2
Externally publishedYes


  • Angiogenesis
  • Energy shortage
  • Inflammation
  • Photoreceptors
  • Retina

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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