Tear Evaporation Rates in Sjögren Syndrome and non-Sjögren Dry Eye Patients

Eiki Goto, Yukihiro Matsumoto, Mizuka Kamoi, Koji Endo, Reiko Ishida, Murat Dogru, Minako Kaido, Takashi Kojima, Kazuo Tsubota

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65 Citations (Scopus)


Purpose: To reinvestigate tear evaporation rates in Sjögren syndrome (SS) and non-Sjögren (non-SS) dry eye patients with a recently reported ventilated chamber evaporimeter system. Design: Prospective case-control study. Methods: A ventilated chamber evaporimeter system was used to measure tear evaporation rates. A DR-1 camera (Kowa, Nagoya, Japan) was used for tear lipid layer interference image acquisition. The Yokoi severity grading system was used for DR-1 image evaluation. Twenty-four aqueous tear deficiency (ATD) eyes of 21 consecutive patients with SS were studied (SS ATD group). Twenty-one ATD eyes of 12 non-SS patients (non-SS ATD group) were examined as control subjects. Results: Tear evaporation rates of the SS ATD group (5.9 ± 3.5 [10-7 g/cm2 per second]) were significantly higher than those of the non-SS ATD group (2.9 ± 1.8 [10-7 g/cm2 per second]; P = .0009). The severity grading of DR-1 tear interference images of the SS ATD group was significantly higher (P = .03), along with significantly worse meibomian gland expressibility and vital staining scores, compared with those of the non-SS ATD group. Conclusions: Tear evaporation rates were higher in eyes of the SS ATD group compared with the non-SS ATD group. Tear evaporation assessed in conjunction with tear lipid layer findings and meibomian gland expressibility provides an increased understanding in the differential diagnosis of dry eye states.

Original languageEnglish
Pages (from-to)81-85.e1
JournalAmerican Journal of Ophthalmology
Issue number1
Publication statusPublished - 2007 Jul

ASJC Scopus subject areas

  • Ophthalmology


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