Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease

Y. Ban; Y. Ogawa; E. Goto; M. Uchino; N. Terauchi; M. Seki; M. Nakaya; M. Saiki; T. Mori; S. Okamoto; Y. Matsumoto; M. Dogru; J. Shimazaki; K. Tsubota

doi:10.1038/eye.2008.340

Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease

Y. Ban, Y. Ogawa, E. Goto, M. Uchino, N. Terauchi, M. Seki, M. Nakaya, M. Saiki, T. Mori, S. Okamoto, Y. Matsumoto, M. Dogru, J. Shimazaki, K. Tsubota

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Purpose: To investigate the changes in the tear film lipid layer in haematopoietic stem cell transplantation (HSCT) patients with dry eye (DE) associated with chronic graft-vs-host disease (cGVHD) and compare with HSCT recipients without DE. Methods: We performed a prospective study in 10 HSCT patients with DE associated with cGVHD and 11 HSCT recipients without DE. We performed Schirmer's test, tear film break up time examinations, ocular surface dye staining and meibum expressibility test and DR-1 tear film lipid layer interferometry. DR-1 interferometry images of the tear film surface were assigned a 'DR-1 grade' according to the Yokoi severity grading system. The DR-1 grades were analysed according to the presence or absence of DE, conjunctival fibrosis and systemic cGVHD. Results: The mean DR-1 severity grade in patients with DE related to cGVHD (DE/cGVHD group; 3.9±0.9) was significantly higher than in patients without DE after HSCT (non-DE/non-cGVHD group; 1.3±0.6; P<0.05). The DR-1 grade for HSCT recipients with conjunctival fibrosis was significantly higher than in patients without conjunctival fibrosis (P<0.05). When DE severity was graded according to the recommendation of the 2007 Dry Eye Workshop Report, our results showed a correlation between the severity of DE and DR-1 grades (r=0.8812, P<0.0001). Conclusion: DR-1 interferometry may be applicable to diagnosing DE and evaluating its progression subsequent to HSCT.

Original language	English
Pages (from-to)	202-208
Number of pages	7
Journal	Eye
Volume	23
Issue number	1
DOIs	https://doi.org/10.1038/eye.2008.340
Publication status	Published - 2009 Jan
Externally published	Yes

Keywords

Bone marrow transplantation
Chronic GVHD
Conjunctival fibrosis
Dry eye
Tear interference
Tear lipid layer

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1038/eye.2008.340

Cite this

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title = "Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease",

abstract = "Purpose: To investigate the changes in the tear film lipid layer in haematopoietic stem cell transplantation (HSCT) patients with dry eye (DE) associated with chronic graft-vs-host disease (cGVHD) and compare with HSCT recipients without DE. Methods: We performed a prospective study in 10 HSCT patients with DE associated with cGVHD and 11 HSCT recipients without DE. We performed Schirmer's test, tear film break up time examinations, ocular surface dye staining and meibum expressibility test and DR-1 tear film lipid layer interferometry. DR-1 interferometry images of the tear film surface were assigned a 'DR-1 grade' according to the Yokoi severity grading system. The DR-1 grades were analysed according to the presence or absence of DE, conjunctival fibrosis and systemic cGVHD. Results: The mean DR-1 severity grade in patients with DE related to cGVHD (DE/cGVHD group; 3.9±0.9) was significantly higher than in patients without DE after HSCT (non-DE/non-cGVHD group; 1.3±0.6; P<0.05). The DR-1 grade for HSCT recipients with conjunctival fibrosis was significantly higher than in patients without conjunctival fibrosis (P<0.05). When DE severity was graded according to the recommendation of the 2007 Dry Eye Workshop Report, our results showed a correlation between the severity of DE and DR-1 grades (r=0.8812, P<0.0001). Conclusion: DR-1 interferometry may be applicable to diagnosing DE and evaluating its progression subsequent to HSCT.",

keywords = "Bone marrow transplantation, Chronic GVHD, Conjunctival fibrosis, Dry eye, Tear interference, Tear lipid layer",

author = "Y. Ban and Y. Ogawa and E. Goto and M. Uchino and N. Terauchi and M. Seki and M. Nakaya and M. Saiki and T. Mori and S. Okamoto and Y. Matsumoto and M. Dogru and J. Shimazaki and K. Tsubota",

note = "Funding Information: This study was supported by Grant nos. 17791254 and 20592058 from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (Tokyo, Japan).",

year = "2009",

month = jan,

doi = "10.1038/eye.2008.340",

language = "English",

volume = "23",

pages = "202--208",

journal = "Eye",

issn = "0950-222X",

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T1 - Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease

AU - Ban, Y.

AU - Ogawa, Y.

AU - Goto, E.

AU - Uchino, M.

AU - Terauchi, N.

AU - Seki, M.

AU - Nakaya, M.

AU - Saiki, M.

AU - Mori, T.

AU - Okamoto, S.

AU - Matsumoto, Y.

AU - Dogru, M.

AU - Shimazaki, J.

AU - Tsubota, K.

N1 - Funding Information: This study was supported by Grant nos. 17791254 and 20592058 from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (Tokyo, Japan).

PY - 2009/1

Y1 - 2009/1

N2 - Purpose: To investigate the changes in the tear film lipid layer in haematopoietic stem cell transplantation (HSCT) patients with dry eye (DE) associated with chronic graft-vs-host disease (cGVHD) and compare with HSCT recipients without DE. Methods: We performed a prospective study in 10 HSCT patients with DE associated with cGVHD and 11 HSCT recipients without DE. We performed Schirmer's test, tear film break up time examinations, ocular surface dye staining and meibum expressibility test and DR-1 tear film lipid layer interferometry. DR-1 interferometry images of the tear film surface were assigned a 'DR-1 grade' according to the Yokoi severity grading system. The DR-1 grades were analysed according to the presence or absence of DE, conjunctival fibrosis and systemic cGVHD. Results: The mean DR-1 severity grade in patients with DE related to cGVHD (DE/cGVHD group; 3.9±0.9) was significantly higher than in patients without DE after HSCT (non-DE/non-cGVHD group; 1.3±0.6; P<0.05). The DR-1 grade for HSCT recipients with conjunctival fibrosis was significantly higher than in patients without conjunctival fibrosis (P<0.05). When DE severity was graded according to the recommendation of the 2007 Dry Eye Workshop Report, our results showed a correlation between the severity of DE and DR-1 grades (r=0.8812, P<0.0001). Conclusion: DR-1 interferometry may be applicable to diagnosing DE and evaluating its progression subsequent to HSCT.

AB - Purpose: To investigate the changes in the tear film lipid layer in haematopoietic stem cell transplantation (HSCT) patients with dry eye (DE) associated with chronic graft-vs-host disease (cGVHD) and compare with HSCT recipients without DE. Methods: We performed a prospective study in 10 HSCT patients with DE associated with cGVHD and 11 HSCT recipients without DE. We performed Schirmer's test, tear film break up time examinations, ocular surface dye staining and meibum expressibility test and DR-1 tear film lipid layer interferometry. DR-1 interferometry images of the tear film surface were assigned a 'DR-1 grade' according to the Yokoi severity grading system. The DR-1 grades were analysed according to the presence or absence of DE, conjunctival fibrosis and systemic cGVHD. Results: The mean DR-1 severity grade in patients with DE related to cGVHD (DE/cGVHD group; 3.9±0.9) was significantly higher than in patients without DE after HSCT (non-DE/non-cGVHD group; 1.3±0.6; P<0.05). The DR-1 grade for HSCT recipients with conjunctival fibrosis was significantly higher than in patients without conjunctival fibrosis (P<0.05). When DE severity was graded according to the recommendation of the 2007 Dry Eye Workshop Report, our results showed a correlation between the severity of DE and DR-1 grades (r=0.8812, P<0.0001). Conclusion: DR-1 interferometry may be applicable to diagnosing DE and evaluating its progression subsequent to HSCT.

KW - Bone marrow transplantation

KW - Chronic GVHD

KW - Conjunctival fibrosis

KW - Dry eye

KW - Tear interference

KW - Tear lipid layer

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Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease

Abstract

Keywords

ASJC Scopus subject areas

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