Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Koji Hase; Shigetoshi Kadota; Purusotam Basnet; Jianxin Li; Shuichi Takamura; Tsuneo Namba

doi:10.1248/cpb.45.567

Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Koji Hase, Shigetoshi Kadota, Purusotam Basnet, Jianxin Li, Shuichi Takamura, Tsuneo Namba

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

Original language	English
Pages (from-to)	567-569
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	3
DOIs	https://doi.org/10.1248/cpb.45.567
Publication status	Published - 1997 Mar
Externally published	Yes

Keywords

D- galactosamine/lipopolysaccharide-induced liver injury
Gentianaceae
Swertia japonica
tetrahydroswertianolin
tetrahydroxanthone

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.45.567

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title = "Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO",

abstract = "Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.",

keywords = "D- galactosamine/lipopolysaccharide-induced liver injury, Gentianaceae, Swertia japonica, tetrahydroswertianolin, tetrahydroxanthone",

author = "Koji Hase and Shigetoshi Kadota and Purusotam Basnet and Jianxin Li and Shuichi Takamura and Tsuneo Namba",

year = "1997",

month = mar,

doi = "10.1248/cpb.45.567",

language = "English",

volume = "45",

pages = "567--569",

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publisher = "Pharmaceutical Society of Japan",

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T2 - A potent hepatoprotective agent from Swertia japonica MAKINO

AU - Hase, Koji

AU - Kadota, Shigetoshi

AU - Basnet, Purusotam

AU - Li, Jianxin

AU - Takamura, Shuichi

AU - Namba, Tsuneo

PY - 1997/3

Y1 - 1997/3

N2 - Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

AB - Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

KW - D- galactosamine/lipopolysaccharide-induced liver injury

KW - Gentianaceae

KW - Swertia japonica

KW - tetrahydroswertianolin

KW - tetrahydroxanthone

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SN - 0009-2363

VL - 45

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EP - 569

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 3

ER -

Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Abstract

Keywords

ASJC Scopus subject areas

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