Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Koji Hase, Shigetoshi Kadota, Purusotam Basnet, Jianxin Li, Shuichi Takamura, Tsuneo Namba

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Tetrahydroswertianolin (1), a new tetrahydroxanthone glycoside, was isolated from the whole plant of Swertia japonica MAKINO (Gentianaceae). Its structure was determined by chemical and spectroscopic methods including 2D- NMR. This compound was found to be very effective in immunologically induced liver injury in mice.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number3
Publication statusPublished - 1997 Mar
Externally publishedYes


  • D- galactosamine/lipopolysaccharide-induced liver injury
  • Gentianaceae
  • Swertia japonica
  • tetrahydroswertianolin
  • tetrahydroxanthone

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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