TY - JOUR
T1 - Thalamic reticular nucleus in the thalamocortical loop
AU - Takata, Norio
N1 - Funding Information:
I thank Manal S. A. Abdelaal and Syunnosuke Inamori for helpful comments on the manuscript. This work was supported by The Ministry of Education, Culture, Sports, Science and Technology (MEXT)/Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP 16H01620 , JP 18H04952 , and JP 19K06944 .
Publisher Copyright:
© 2019 Elsevier B.V. and Japan Neuroscience Society
PY - 2020/7
Y1 - 2020/7
N2 - Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-level physiological studies of the rodent TRN. Diversity and heterogeneity of TRN neurons in terms of axonal innervation, molecular expression, and physiological characteristics are described. I also outline thalamocortical and cortico-cortical connections with emphasis on interaction with the TRN. In summary, it is proposed that functional connectivity among brain regions are modulated with gating of transthalamic information flow by the TRN.
AB - Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-level physiological studies of the rodent TRN. Diversity and heterogeneity of TRN neurons in terms of axonal innervation, molecular expression, and physiological characteristics are described. I also outline thalamocortical and cortico-cortical connections with emphasis on interaction with the TRN. In summary, it is proposed that functional connectivity among brain regions are modulated with gating of transthalamic information flow by the TRN.
KW - Cortex
KW - Corticocortical loop
KW - Functional connectivity
KW - Thalamic reticular nucleus
KW - Thalamocortical loop
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?scp=85076514545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076514545&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2019.12.004
DO - 10.1016/j.neures.2019.12.004
M3 - Review article
C2 - 31812650
AN - SCOPUS:85076514545
SN - 0168-0102
VL - 156
SP - 32
EP - 40
JO - Neuroscience Research
JF - Neuroscience Research
ER -