TY - JOUR
T1 - The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system
AU - Takeuchi, Tsutomu
AU - Schlossman, Stuart F.
AU - Morimoto, Chikao
N1 - Funding Information:
’ This work was supported by NIH Grants AI 12069, CA 19589, and AM 337 13. * Dr. Takeuchi is a recipient of the postdoctoral fellowship from the Cancer Research Institute, NY. 3 Abbreviations used: AMLR, autologous mixed lymphocyte reaction; MHC, major histocompatibility complex; PWM, pokeweed mitogen; Ig, immunoglobulin; TPA, 12-O-tetradecanoylphorbol-13-acetate; RIA, radioimmunoassay.
PY - 1987/6
Y1 - 1987/6
N2 - It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.
AB - It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200 220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.
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U2 - 10.1016/0008-8749(87)90270-X
DO - 10.1016/0008-8749(87)90270-X
M3 - Article
C2 - 2953440
AN - SCOPUS:0023229023
SN - 0008-8749
VL - 107
SP - 107
EP - 114
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -