The apolipoprotein E gene in Binswanger's disease and vascular dementia

Susumu Higuchi, Hiroyuki Arai, Takuma Nakagawa, Taro Muramatsu, Hidetada Sasaki, John Q. Trojanowski

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalClinical Genetics
Issue number6
Publication statusPublished - 1996 Dec
Externally publishedYes


  • Alzheimer's disease
  • Apolipoprotein E
  • Binswanger's disease
  • Polymorphism
  • Vascular dementia

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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