The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug

Yujiro Hayashi, Mitsuru Shoji, Hayato Ishikawa, Junichiro Yamaguchi, Tomohiro Tamura, Hiroki Imai, Yosuke Nishigaya, Kenichi Takabe, Hideaki Kakeya, Hiroyuki Osada

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


(Chemical Equation Presented) A star-studded lineup: (+)-Cytotrienin A was the target of an asymmetric total synthesis featuring an enantioselective aldol reaction, α-aminoxylation, deoxygenation, and a ring-closing metathesis to form the 21-membered macrolactam. This first total synthesis confirms the relative and absolute confguration of the molecule.

Original languageEnglish
Pages (from-to)6657-6660
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number35
Publication statusPublished - 2008 Aug 18
Externally publishedYes


  • Aldol reaction
  • Asymmetric synthesis
  • Organocatalysis
  • Ring-closing metathesis
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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