The Baylis-Hillman reaction under high pressure induced by water-freezing

Yujiro Hayashi, Kotaro Okado, Itaru Ashimine, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


High pressure (about 200 MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to the Baylis-Hillman reaction, in which an efficient rate enhancement was observed.

Original languageEnglish
Pages (from-to)8683-8686
Number of pages4
JournalTetrahedron Letters
Issue number48
Publication statusPublished - 2002 Nov 25
Externally publishedYes


  • Baylis-Hillman reaction
  • High-pressure
  • Water-freezing

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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