The chiral diamine mediated asymmetric Baylis-Hillman reaction

Yujiro Hayashi, Tomohiro Tamura, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


A chiral diamine, easily prepared from proline, is an effective, asymmetric organic catalyst for the Baylis-Hillman reaction of aldehydes and methyl vinyl ketone, affording adducts with enantio-selectivities up to 75%.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalAdvanced Synthesis and Catalysis
Issue number9-10
Publication statusPublished - 2004 Aug
Externally publishedYes


  • Asymmetric synthesis
  • Baylis-Hillman reaction
  • Diamines
  • Enones
  • Lewis base catalysts
  • Organic catalysis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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