TY - GEN
T1 - The contribution of blood oxygenation changes in the capillary bed and a small blood vessel on the brain surface to NIRS signals
AU - Honjyo, Kazushi
AU - Okada, Eiji
AU - Maki, Atsushi
AU - Delpy, David T.
N1 - Funding Information:
In this study, we investigated the contribution of blood oxygenation change in the capillary bed and a larger blood vessel on the brain surface to the NIRS signal. The capillary bed in the brain tissue contributes more to the NIRS signal than the larger blood vessel on the brain surface. Although photons passing through the blood vessel on the brain surface also arrive at the detector, their contribution to the NIRS signal can probably be ignored unless there is a significant oxygenation change in them. This work was partly supported by TEPCO Research Foundation, the Ministry of Education, Science and Culture of Japan under a Grant-in-Aid for Developmental Scientific Research No. 012-10091047.
Publisher Copyright:
© 1999 Optical Society of America.
PY - 2000
Y1 - 2000
N2 - Changes in the optical density of the brain measured by near infrared spectroscopy (NIRS) instruments reflect blood oxygenation changes in the various blood vessels in the brain. Light propagation in a model of the head predicted by a Monte Carlo simulation has been used to estimate the contribution of blood oxygenation change in the capillary bed and in larger blood vessels in the brain to NIRS signal. Results show that the effective partial path length in the brain tissue is much longer than that in the blood vessel on the brain surface and that blood oxygenation change in the capillary bed are me major contributors to the change in the NIRS signal.
AB - Changes in the optical density of the brain measured by near infrared spectroscopy (NIRS) instruments reflect blood oxygenation changes in the various blood vessels in the brain. Light propagation in a model of the head predicted by a Monte Carlo simulation has been used to estimate the contribution of blood oxygenation change in the capillary bed and in larger blood vessels in the brain to NIRS signal. Results show that the effective partial path length in the brain tissue is much longer than that in the blood vessel on the brain surface and that blood oxygenation change in the capillary bed are me major contributors to the change in the NIRS signal.
UR - http://www.scopus.com/inward/record.url?scp=0004098907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0004098907&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0004098907
T3 - Optics InfoBase Conference Papers
SP - 289
EP - 291
BT - Biomedical Optical Spectroscopy and Diagnostics, BOSD 2000
PB - Optica Publishing Group (formerly OSA)
T2 - Biomedical Optical Spectroscopy and Diagnostics, BOSD 2000
Y2 - 2 April 2000
ER -