The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients

Takashi Kasahara; Kentaro Terasaki; Yuki Ogawa; Junichi Ushiba; Harumichi Aramaki; Yoshihisa Masakado

doi:10.1186/1471-2202-13-66

The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients

Takashi Kasahara, Kentaro Terasaki, Yuki Ogawa, Junichi Ushiba, Harumichi Aramaki, Yoshihisa Masakado

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Background: The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.Results: The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.Conclusions: ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.

Original language	English
Article number	66
Journal	BMC Neuroscience
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2202-13-66
Publication status	Published - 2012 Jun 15

Keywords

Amyotrophic lateral sclerosis
Brain-computer interface
Bulbar dysfunction

ASJC Scopus subject areas

Neuroscience(all)
Cellular and Molecular Neuroscience

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10.1186/1471-2202-13-66

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title = "The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients",

abstract = "Background: The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.Results: The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.Conclusions: ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.",

keywords = "Amyotrophic lateral sclerosis, Brain-computer interface, Bulbar dysfunction",

author = "Takashi Kasahara and Kentaro Terasaki and Yuki Ogawa and Junichi Ushiba and Harumichi Aramaki and Yoshihisa Masakado",

note = "Funding Information: We wish to thank Naoki Onodera M.D. of Department of Neurology and Satoru Sone RPT of Department of Rehabilitation, Tsurumaki Onsen Hospital for the technical assistance with the experiment. This study was supported from “Brain Machine Interface Development” under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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doi = "10.1186/1471-2202-13-66",

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AU - Ushiba, Junichi

AU - Aramaki, Harumichi

AU - Masakado, Yoshihisa

N1 - Funding Information: We wish to thank Naoki Onodera M.D. of Department of Neurology and Satoru Sone RPT of Department of Rehabilitation, Tsurumaki Onsen Hospital for the technical assistance with the experiment. This study was supported from “Brain Machine Interface Development” under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Y1 - 2012/6/15

N2 - Background: The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.Results: The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.Conclusions: ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.

AB - Background: The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.Results: The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.Conclusions: ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.

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KW - Brain-computer interface

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The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients

Abstract

Keywords

ASJC Scopus subject areas

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