Abstract
A basic investigation aimed at developing a membrane-controlled transdermal therapeutic system was carried out. The drug used was molsidomine with oleic acid and propylene glycol as the absorption enhancer and the vehicle, respectively. It was concluded that a microporous polyethylene membrane was most suitable for release control. A desirable pattern of the molsidomine plasma concentration versus time curve could be obtained by controlling the amounts of the three components, molsidomine, oleic acid, and propylene glycol in the device. Furthermore, the plasma concentration of molsidomine was well sustained by adding polyethyleneglycol 400 to the oleic acid-propylene glycol solution.
| Original language | English |
|---|---|
| Pages (from-to) | 3407-3412 |
| Number of pages | 6 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1987 Jan 1 |
| Externally published | Yes |
Keywords
- Keywords-molsidomine
- controlled release
- drug delivery system
- microporous membrane
- transdermal
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery