The diet-microbiota-metabolite axis regulates the host physiology

Takahiro Yamada, Daisuke Takahashi, Koji Hase

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


The intestinal microbiota has been implicated in a wide range of diseases, including inflammatory bowel disease, obesity and cancer. Food ingredients are considered a major determinant of gut microbial composition, as exemplified by high-fat diet-induced dysbiosis that can affect host physiology. Accumulating studies show that microbial metabolites are key regulators of the intestinal epithelial barrier and gut immunity. In particular, shortchain fatty acids produced by bacterial fermentation of indigestible polysaccharides have profound impacts on host physiology beyond the gut. In this review, we describe the influences of the diet-microbiota-metabolite axis on host physiology, and especially on the immune and metabolic systems.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of biochemistry
Issue number1
Publication statusPublished - 2016 Jul


  • Commensal microbiota
  • Diet
  • Epithelial barrier
  • Immune system
  • Short chain fatty acid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'The diet-microbiota-metabolite axis regulates the host physiology'. Together they form a unique fingerprint.

Cite this