The effect of an air purifier on aerosol generation measurements during clinical motility testing

Wout Verbeure, Annelies Geeraerts, I. Hsuan Huang, Lien Timmermans, Joran Tóth, Hannelore Geysen, Louise Cools, Florencia Carbone, Jolien Schol, Herman Devriese, Rico Haesaerts, Hideki Mori, Tim Vanuytsel, Jan Tack

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Aerosol spread is key to interpret the risk of viral contamination during clinical procedures such as esophageal high-resolution manometry (HRM). Installing an air purifier seems a legitimate strategy, but this has recently been questioned. Methods: Patients undergoing an HRM procedure at the Leuven University Hospital were included in this clinical study. All subjects had to wear a surgical mask which was only lowered beneath the nose during the placement and removal of the nasogastric catheter. The number of aerosol particles was measured by a Lasair® II Particle Counter to obtain data about different particles sizes: 0.3; 0.5; 1.0; 3.0; 5.0; and 10.0 µm. Measurements were done immediately before the placement and the removal of the HRM catheter, and one and 5 min after. A portable air purifier with high-efficiency particle air filters was installed in the hospital room. Key Results: Thirteen patients underwent a manometry examination. The amount of 0.3 µm-sized particles was unaffected during the whole procedure. The larger particle sizes (1.0; 3.0; 5.0; and 10.0 µm) decreased when the catheter was positioned, but not 0.5 µm. During the HRM measurements itself, these numbers decreased further. Yet, 1 min after catheter removal a significant elevation of particles was seen, which did not recover within 5 min. Conclusions & Interferences: Based on this study, there is no evidence that filtration systems reduce aerosol particles properly during a clinical investigation.

Original languageEnglish
Article numbere14227
JournalNeurogastroenterology and Motility
Issue number4
Publication statusPublished - 2022 Apr
Externally publishedYes


  • COVID19
  • aerosol
  • air purifier
  • nasogastric intubation

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


Dive into the research topics of 'The effect of an air purifier on aerosol generation measurements during clinical motility testing'. Together they form a unique fingerprint.

Cite this