The first case of concomitant Mycobacterium Genavense lymphadenitis and EBV-positive lymphoproliferative disorder

Yusuke Ito, Kensuke Takaoka, Kazuhiro Toyama, Kazuki Taoka, Yoshitaka Wakabayashi, Aya Shinozaki-Ushiku, Aiko Okazaki, Kinuyo Chikamatsu, Satoshi Mitarai, Tetsuo Ushiku, Mineo Kurokawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This is the first case of concurrent Mycobacterium genavense lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history. M. genavense infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce the M. genavense lymphadenitis. This case highly alerts clinicians to the immunosuppressive state of EBV-positive LPD with latency type III even if any immunodeficient serological factors are not detected.

Original languageEnglish
Article numbere2020035
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume12
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Epstein-Barr virus-positive lymphoproliferative disorder (EBV-LPD)
  • Mycobacterium genavense
  • Programmed cell death 1 ligand 1 (PD-L1)

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

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