The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

K. Matoishi; S. Hanzawa; H. Kakidani; M. Suzuki; T. Sugai; H. Ohta

doi:10.1039/b003941l

The first synthesis of both enantiomers of [α-²H]phenylacetic acid in high enantiomeric excess

K. Matoishi, S. Hanzawa, H. Kakidani, M. Suzuki, T. Sugai, H. Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-²H]- and [α-¹H]phenylmalonic acid in ¹H₂O and ²H₂O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-²H]phenylacetic acid in quantitative yields.

Original language	English
Pages (from-to)	1519-1520
Number of pages	2
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/b003941l
Publication status	Published - 2000 Aug 21

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-2H]- and [α-1H]phenylmalonic acid in 1H2O and 2H2O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-2H]phenylacetic acid in quantitative yields.",

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AU - Matoishi, K.

AU - Hanzawa, S.

AU - Kakidani, H.

AU - Suzuki, M.

AU - Sugai, T.

AU - Ohta, H.

PY - 2000/8/21

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AB - Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-2H]- and [α-1H]phenylmalonic acid in 1H2O and 2H2O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-2H]phenylacetic acid in quantitative yields.

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The first synthesis of both enantiomers of [α-²H]phenylacetic acid in high enantiomeric excess

Abstract

ASJC Scopus subject areas

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