The HfCl4-mediated Diels-Alder reaction of furan

Yujiro Hayashi, Masahiko Nakamura, Shigehiro Nakao, Tae Inoue, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


High yields and high endo selectivity of the cycloadducts formed from the Diels-Alder reaction of furan or substituted furans occurs with an HfCl4 catalyst (see scheme). The use of the catalyst allows reactions to be performed at low temperature under kinetic control, as shown for the highly diastereoselective Diels-Alder reaction of a chiral acrylate.

Original languageEnglish
Pages (from-to)4079-4082
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number21
Publication statusPublished - 2002 Nov 4
Externally publishedYes


  • Asymmetric synthesis
  • Cycloaddition
  • Furanes
  • Hafnium
  • Pericyclic reaction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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