The human genes for desmogleins (dsg1 and dsg3) are located in a small region on chromosome 18q12

Yimin Wang; Masayuki Amagai; Shinsei Minoshima; Kosuke Sakai; Kathleen J. Green; Takeji Nishikawa; Nobuyoshi Shimizu

doi:10.1006/geno.1994.1207

The human genes for desmogleins (dsg1 and dsg3) are located in a small region on chromosome 18q12

Yimin Wang, Masayuki Amagai, Shinsei Minoshima, Kosuke Sakai, Kathleen J. Green, Takeji Nishikawa, Nobuyoshi Shimizu

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Desmoglein is a transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Two of the three currently known desmogleins are the autoantigens of autoimmune skin blistering diseases, pemphigus vulgaris and pemphigus foliaceus, in which autoantibodies cause the loss of cell adhesion of keratinocytes with resultant blister formation. In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization. Furthermore, both genes were localized on a 320-kb genomic fragment separated by pulsed-field gel electrophoresis. These results suggest the possibility of a cluster for the desmoglein gene family on chromosome 18.

Original language	English
Pages (from-to)	492-495
Number of pages	4
Journal	Genomics
Volume	20
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1207
Publication status	Published - 1994 Apr

ASJC Scopus subject areas

Genetics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/geno.1994.1207

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title = "The human genes for desmogleins (dsg1 and dsg3) are located in a small region on chromosome 18q12",

abstract = "Desmoglein is a transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Two of the three currently known desmogleins are the autoantigens of autoimmune skin blistering diseases, pemphigus vulgaris and pemphigus foliaceus, in which autoantibodies cause the loss of cell adhesion of keratinocytes with resultant blister formation. In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization. Furthermore, both genes were localized on a 320-kb genomic fragment separated by pulsed-field gel electrophoresis. These results suggest the possibility of a cluster for the desmoglein gene family on chromosome 18.",

author = "Yimin Wang and Masayuki Amagai and Shinsei Minoshima and Kosuke Sakai and Green, {Kathleen J.} and Takeji Nishikawa and Nobuyoshi Shimizu",

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AU - Wang, Yimin

AU - Amagai, Masayuki

AU - Minoshima, Shinsei

AU - Sakai, Kosuke

AU - Green, Kathleen J.

AU - Nishikawa, Takeji

AU - Shimizu, Nobuyoshi

PY - 1994/4

Y1 - 1994/4

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AB - Desmoglein is a transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Two of the three currently known desmogleins are the autoantigens of autoimmune skin blistering diseases, pemphigus vulgaris and pemphigus foliaceus, in which autoantibodies cause the loss of cell adhesion of keratinocytes with resultant blister formation. In this study, the genes for two autoantigens (DSG1 for pemphigus foliaceus and DSG3 for pemphigus vulgaris) were mapped on band q12 of human chromosome 18 by fluorescence in situ hybridization. Furthermore, both genes were localized on a 320-kb genomic fragment separated by pulsed-field gel electrophoresis. These results suggest the possibility of a cluster for the desmoglein gene family on chromosome 18.

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The human genes for desmogleins (dsg1 and dsg3) are located in a small region on chromosome 18q12

Abstract

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UN SDGs

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