TY - JOUR
T1 - The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives
AU - Yasuno, Takumi
AU - Ohe, Tomoyuki
AU - Takahashi, Kyoko
AU - Nakamura, Shigeo
AU - Mashino, Tadahiko
N1 - Funding Information:
This work was supported by Health Labor Sciences Research Grant from the Ministry of Health, Labor, and Welfare of Japan ( MHLW ) and by Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( MEXT ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/7/3
Y1 - 2015/7/3
N2 - Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.
AB - Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.
KW - Abbreviations ART antiretroviral therapy
KW - HIV human immunodeficiency virus
KW - HIV-RT human immunodeficiency virus-reverse transcriptase
KW - PMB p-methoxybenzyl
UR - http://www.scopus.com/inward/record.url?scp=84934850144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934850144&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2015.05.086
DO - 10.1016/j.bmcl.2015.05.086
M3 - Article
C2 - 26081290
AN - SCOPUS:84934850144
SN - 0960-894X
VL - 25
SP - 3226
EP - 3229
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 16
M1 - 22776
ER -
