TY - JOUR
T1 - The immunostimulatory effects of a traditional herbal (Kampo) medicine, Sho-saiko-to in mice
T2 - A possible influence on drug-induced lymphocyte stimulation test
AU - Ohtake, Nobuhiro
AU - Watanabe, Kenji
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003
Y1 - 2003
N2 - We evaluated the effects of Kampo-medicines (Sho-saiko-to, Keishi-bukuryo-gann and Mao-bushi-saishin-to), or various mitogens (concanavalin A, anti-CD 3 monoclonal antibody and lipopolysaccharide) on drug-induced lymphocyte stimulation test (DLST). BALB/c mice were administered orally with Sho-saiko-to (SST) or vehicle (Control). In Control splenocytes, Sho-saiko-to showed mitogenic activity, and the constituent herb Kanzo had the strongest activity. In SST splenocytes, cytokine production by anti-CD 3 and mitogenic response by all mitogenes and medicines were enhanced. Some modulations in immune response were found also in SST hepatic mononuclear cells. The immunostimulatory activity of Sho-saiko-to, as a polyclonal mitogen in vitro and as an immunopotentiator in vivo, may confuse the diagnosis for side effects of Kampo-medicines using DLST.
AB - We evaluated the effects of Kampo-medicines (Sho-saiko-to, Keishi-bukuryo-gann and Mao-bushi-saishin-to), or various mitogens (concanavalin A, anti-CD 3 monoclonal antibody and lipopolysaccharide) on drug-induced lymphocyte stimulation test (DLST). BALB/c mice were administered orally with Sho-saiko-to (SST) or vehicle (Control). In Control splenocytes, Sho-saiko-to showed mitogenic activity, and the constituent herb Kanzo had the strongest activity. In SST splenocytes, cytokine production by anti-CD 3 and mitogenic response by all mitogenes and medicines were enhanced. Some modulations in immune response were found also in SST hepatic mononuclear cells. The immunostimulatory activity of Sho-saiko-to, as a polyclonal mitogen in vitro and as an immunopotentiator in vivo, may confuse the diagnosis for side effects of Kampo-medicines using DLST.
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U2 - 10.2957/kanzo.44.194
DO - 10.2957/kanzo.44.194
M3 - Article
AN - SCOPUS:0038801427
SN - 0451-4203
VL - 44
SP - 194
EP - 203
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
IS - 5
ER -