TY - JOUR
T1 - The Impact of Nasal Conjunctivochalasis on Tear Functions and Ocular Surface Findings
AU - Wang, Yan
AU - Dogru, Murat
AU - Matsumoto, Yukihiro
AU - Ward, Samantha K.
AU - Ayako, Igarashi
AU - Hu, Yiqian
AU - Okada, Naoko
AU - Ogawa, Yoko
AU - Shimazaki, Jun
AU - Tsubota, Kazuo
N1 - Funding Information:
This study was supported by the Johnson & Johnson Vision Care Company, Tokyo, Japan. The authors indicate no financial conflict of interest. Involved in design of study (M.D., Y.M., Y.W., J.S., K.T.); conduct of study (Y.W., M.D., Y.M., S.W., I.A., Y.H., Y.O., N.O.); data collection and analysis (Y.W., M.D., Y.M., S.W., I.A., Y.H., N.O., Y.O.); preparation (Y.W., M.D.) and review and approval (M.D., Y.M., J.S., K.T.) of the manuscript. The study followed the Tenets of the Declaration of Helsinki. Informed consents were obtained from each patient. Examination procedures were Ethic board reviewed.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2007/12
Y1 - 2007/12
N2 - Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.
AB - Purpose: To investigate the effect of grade 3 nasal conjunctivochalasis (NCCh) on the tear film inflammation, ocular surface findings, and tear function findings. Design: Prospective, observational case series. Methods: Eleven eyes with Yokoi grade 3 NCCh in which the chalatic conjunctiva occluded the punctum and 18 eyes without NCCh but with central or temporal conjunctivochalasis, or both, and 16 eyes of healthy controls were recruited prospectively. Enzyme-linked immunosorbent assay for inflammatory tear cytokines, tear film break-up time (BUT), Schirmer I test measurements, and fluorescein and rose bengal vital stainings and impression cytologic and brush cytologic analysis for real-time reverse-transcriptase polymerase chain reaction analysis of MUC5AC messenger ribonucleic acid (mRNA) expression were performed. Results: Eyes with grade 3 NCCh had significantly delayed tear clearance. All inflammatory cytokines showed higher values in eyes with grade 3 NCCh compared with the eyes without nasal chalasis with a comparably significant elevation in interleukin-1b and tumor necrosis factor α levels. The mean rose bengal score in eyes with grade 3 NCCh was significantly higher compared with eyes without nasal chalasis and eyes of controls. The mean goblet cell density was significantly lower in eyes with grade 3 NCCh with downregulation of the relative MUC5AC mRNA expression. Conclusions: Inflammation plays an important role in the pathogenesis of conjunctivochalasis and is more pronounced in eyes with nasal chalasis. Pooling of inflammatory cytokines in tears of patients with NCCh associated with delayed tear clearance induces distinct adverse effects that affect the ocular surface health.
UR - http://www.scopus.com/inward/record.url?scp=36248943130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248943130&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2007.07.037
DO - 10.1016/j.ajo.2007.07.037
M3 - Article
C2 - 17916317
AN - SCOPUS:36248943130
SN - 0002-9394
VL - 144
SP - 930-937.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -