The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament

Keiichi Katsumi, Takashi Hirai, Toshitaka Yoshii, Satoshi Maki, Kanji Mori, Narihito Nagoshi, Soraya Nishimura, Kazuhiro Takeuchi, Shuta Ushio, Takeo Furuya, Kei Watanabe, Norihiro Nishida, Kota Watanabe, Takashi Kaito, Satoshi Kato, Katsuya Nagashima, Masao Koda, Kenyu Ito, Shiro Imagama, Yuji MatsuokaKanichiro Wada, Atsushi Kimura, Tetsuro Ohba, Hiroyuki Katoh, Yukihiro Matsuyama, Hiroshi Ozawa, Hirotaka Haro, Katsushi Takeshita, Masahiko Watanabe, Morio Matsumoto, Masaya Nakamura, Masashi Yamazaki, Atsushi Okawa, Yoshiharu Kawaguchi

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3 Citations (Scopus)


Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. The bridging of ossified lesions to the vertebral body gradually increases, thereby decreasing the mobility of the cervical spine; thus, cervical spine function may decrease over time. However, cervical spine function in patients with cervical OPLL has not been evaluated in large prospective studies. Therefore, we conducted a prospective multicenter study to clarify whether ossification spread can influence cervical spine function and quality of life (QOL) in patients with cervical OPLL. In total, 238 patients (162 men, 76 women; mean age, 63.9 years) were enrolled from 16 institutions. Each patient underwent whole spine computed tomography and was evaluated for cervical spine function and QOL using the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). In the multivariate regression analysis, a higher neck VAS score and a larger number of bridge formations of OPLL in the whole spine were significant predictors of adverse outcomes related to cervical spine function. This is the first prospective multicenter study to reveal the impact of ossification spread on cervical spine function. These findings are important to understand the natural course of OPLL and can serve as controls when evaluating postoperative cervical spine function.

Original languageEnglish
Article number14337
JournalScientific reports
Issue number1
Publication statusPublished - 2021 Dec

ASJC Scopus subject areas

  • General


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