TY - JOUR
T1 - The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings
AU - Onguchi, Tatsuya
AU - Dogru, Murat
AU - Okada, Naoko
AU - Kato, Naoko Asano
AU - Tanaka, Mari
AU - Takano, Yoji
AU - Fukagawa, Kazumi
AU - Shimazaki, Jun
AU - Tsubota, Kazuo
AU - Fujishima, Hiroshi
N1 - Funding Information:
This work was supported by a research grant of the Japan Society for the Promotion of Science (JSPS Grant 02261).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2006/3
Y1 - 2006/3
N2 - PURPOSE: To investigate the tear and ocular surface findings between controls, children, and adults with atopic keratoconjunctivitis (AKC). DESIGN: Prospective comparative study. METHODS: Twenty eyes of 10 childhood-onset, 10 eyes of five adult-onset, AKC adult patients, and 12 eyes of six children with infantile-onset AKC, 14 eyes of seven normal adults and seven normal children were recruited. Corneal aesthesiometry, Schirmer test, tear film break-up time (BUT), vital staining, and conjunctival impression cytology were performed. RESULTS: The Schirmer and Rose Bengal scores in childhood-onset adult AKC patients were considerably worse than adult-onset adult AKC patients, pediatric subjects, and the controls (P < .05). The same significant relation was observed in impression cytology parameters. CONCLUSIONS: Ocular surface disease in childhood-onset adult AKC patients was characterized by greater ocular surface epithelial damage. Prolonged inflammation may be important in the evolution and progression of ocular surface disease in patients with longstanding active AKC.
AB - PURPOSE: To investigate the tear and ocular surface findings between controls, children, and adults with atopic keratoconjunctivitis (AKC). DESIGN: Prospective comparative study. METHODS: Twenty eyes of 10 childhood-onset, 10 eyes of five adult-onset, AKC adult patients, and 12 eyes of six children with infantile-onset AKC, 14 eyes of seven normal adults and seven normal children were recruited. Corneal aesthesiometry, Schirmer test, tear film break-up time (BUT), vital staining, and conjunctival impression cytology were performed. RESULTS: The Schirmer and Rose Bengal scores in childhood-onset adult AKC patients were considerably worse than adult-onset adult AKC patients, pediatric subjects, and the controls (P < .05). The same significant relation was observed in impression cytology parameters. CONCLUSIONS: Ocular surface disease in childhood-onset adult AKC patients was characterized by greater ocular surface epithelial damage. Prolonged inflammation may be important in the evolution and progression of ocular surface disease in patients with longstanding active AKC.
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U2 - 10.1016/j.ajo.2005.09.032
DO - 10.1016/j.ajo.2005.09.032
M3 - Article
C2 - 16490512
AN - SCOPUS:33144484833
SN - 0002-9394
VL - 141
SP - 569-571.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -