TY - JOUR
T1 - The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines
AU - Ishiwada, Naruhiko
AU - Hishiki, Haruka
AU - Nagasawa, Koo
AU - Naito, Sachiko
AU - Sato, Yasunori
AU - Chang, Bin
AU - Sasaki, Yuko
AU - Kimura, Kouji
AU - Ohnishi, Makoto
AU - Shibayama, Keigo
N1 - Funding Information:
Conflict of interest: NI has recently received lecture and other fees from Pfizer. All other authors report no potential conflicts. Funding: This study was financially supported by the Japanese Ministry of Health, Labor and Welfare Japan (H24-Shinkou-Ippan-003) grants for Research on Regulatory Science of Pharmaceuticals and Medical Devices and the Research Project for Emerging and Re-Emerging Infectious Disease (H25-Shinkou-Shitei-003).
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014
Y1 - 2014
N2 - The Haemophilus influenzae type b (Hib) vaccine and the heptavalent pneumococcal conjugate vaccine (PCV7) were introduced in Japan in 2008 and 2010, respectively. In 2011, immunization with these two vaccines was encouraged throughout Japan through a governmental program. Children treated in Chiba prefecture for culture-proven invasive H. influenzae disease (IHiD) and invasive Streptococcus pneumoniae disease (IPD) were identified in a prefectural surveillance study from 2008 to 2013. The incidence rate ratio (IRR) and its confidence interval (CI) were calculated to compare the 3 years before and after governmental financial support for vaccination. The average number of IHiD and IPD cases among children <5 years of age in 2011-2013 decreased 84% (IRR: 0.16, 95% CI: 0.09-0.26, p < 0.0001) and 51% (IRR: 0.49, 95% CI: 0.37-0.63, p < 0.0001) compared with those occurring in 2008-2010. The most common non-PCV7 serotype encountered in 2011 and 2013 was 19A. After governmental subsidization of Hib and PCV7 vaccination, IHiD and IPD decreased in Chiba prefecture, Japan. Continuous surveillance is necessary to determine the effectiveness of these two vaccines and for detection of emerging invasive serotypes.
AB - The Haemophilus influenzae type b (Hib) vaccine and the heptavalent pneumococcal conjugate vaccine (PCV7) were introduced in Japan in 2008 and 2010, respectively. In 2011, immunization with these two vaccines was encouraged throughout Japan through a governmental program. Children treated in Chiba prefecture for culture-proven invasive H. influenzae disease (IHiD) and invasive Streptococcus pneumoniae disease (IPD) were identified in a prefectural surveillance study from 2008 to 2013. The incidence rate ratio (IRR) and its confidence interval (CI) were calculated to compare the 3 years before and after governmental financial support for vaccination. The average number of IHiD and IPD cases among children <5 years of age in 2011-2013 decreased 84% (IRR: 0.16, 95% CI: 0.09-0.26, p < 0.0001) and 51% (IRR: 0.49, 95% CI: 0.37-0.63, p < 0.0001) compared with those occurring in 2008-2010. The most common non-PCV7 serotype encountered in 2011 and 2013 was 19A. After governmental subsidization of Hib and PCV7 vaccination, IHiD and IPD decreased in Chiba prefecture, Japan. Continuous surveillance is necessary to determine the effectiveness of these two vaccines and for detection of emerging invasive serotypes.
KW - Children
KW - Haemophilus influenzae
KW - Invasive disease
KW - Japan
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=84922401789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922401789&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2014.07.100
DO - 10.1016/j.vaccine.2014.07.100
M3 - Article
C2 - 25131741
AN - SCOPUS:84922401789
SN - 0264-410X
VL - 32
SP - 5425
EP - 5431
JO - Vaccine
JF - Vaccine
IS - 42
ER -
