The lung as a possible target organ for atrial natriuretic polypeptide secreted from the heart

Makoto Sakamoto, Kazuwa Nakao, Narito Morii, Akira Sugawara, Takayuki Yamada, Hiroshi Itoh, Shozo Shiono, Yoshihiko Saito, Hiroo Imura

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56 Citations (Scopus)


Using a specific radioimmunoassay (RIA) for α-rat atrial natriuretic polypeptide (α-rANP), we have demonstrated the presence of a considerable amount (6.10 ± 0.38 ng/g) (mean ± SE) of α-rANP-like immunoreactivity (α-rANP-LI) in the rat lung, the first organ through which atrial natriuretic polypeptide (ANP) released from the heart passes. High performance gel permeation chromatography coupled with the RIA revealed that most of α-rANP-LI eluted at the position of a low molecular weight form corresponding to synthetic α-rANP. In 2- or 5-day water-deprived rats, the concentration and content of α-rANP-LI in the lung decreased significantly compared with those of control rats. In addition, water-deprivation induced a significant decrease in the plasma concentration of α-rANP-LI simultaneously determined. There was a significant positive correlation between the concentrations of α-rANP-LI in the lung and plasma (r=0.591, P<0.01). These results indicate the presence of ANP in the lung and suggest physiological roles of ANP in pulmonary function.

Original languageEnglish
Pages (from-to)515-520
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1986 Mar 13
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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