The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata

Noriko Shimizu; Masashi Tomoda; Ryoko Gonda; Mieko Kanari; Noriko Takanashi; Nahoko Takahashi

doi:10.1248/cpb.37.1329

The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata

Noriko Shimizu, Masashi Tomoda, Ryoko Gonda, Mieko Kanari, Noriko Takanashi, Nahoko Takahashi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: d-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35 % of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, ¹³C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysac-charide has the α-l→4-linked D-galacturonan backbone bearing α-l→5-linked L-arabino-β-3,6-branched D-galactan side chains.

Original language	English
Pages (from-to)	1329-1332
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	37
Issue number	5
DOIs	https://doi.org/10.1248/cpb.37.1329
Publication status	Published - 1989

Keywords

6-galactan immunological activity reticuloendothelial system methylation analysis controlled Smith degradation structural feature
Saposhnikovia divaricata polysaccharide saposhnikovan A pectic arabino-3

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata",

abstract = "The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: d-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35 % of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysac-charide has the α-l→4-linked D-galacturonan backbone bearing α-l→5-linked L-arabino-β-3,6-branched D-galactan side chains.",

keywords = "6-galactan immunological activity reticuloendothelial system methylation analysis controlled Smith degradation structural feature, Saposhnikovia divaricata polysaccharide saposhnikovan A pectic arabino-3",

author = "Noriko Shimizu and Masashi Tomoda and Ryoko Gonda and Mieko Kanari and Noriko Takanashi and Nahoko Takahashi",

year = "1989",

doi = "10.1248/cpb.37.1329",

language = "English",

volume = "37",

pages = "1329--1332",

journal = "Chemical and Pharmaceutical Bulletin",

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T1 - The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata

AU - Shimizu, Noriko

AU - Tomoda, Masashi

AU - Gonda, Ryoko

AU - Kanari, Mieko

AU - Takanashi, Noriko

AU - Takahashi, Nahoko

PY - 1989

Y1 - 1989

N2 - The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: d-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35 % of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysac-charide has the α-l→4-linked D-galacturonan backbone bearing α-l→5-linked L-arabino-β-3,6-branched D-galactan side chains.

AB - The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: d-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35 % of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysac-charide has the α-l→4-linked D-galacturonan backbone bearing α-l→5-linked L-arabino-β-3,6-branched D-galactan side chains.

KW - 6-galactan immunological activity reticuloendothelial system methylation analysis controlled Smith degradation structural feature

KW - Saposhnikovia divaricata polysaccharide saposhnikovan A pectic arabino-3

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The Major Pectic Arabinogalactan Having Activity on the Reticuloendothelial System from the Roots and Rhizomes of Saposhnikovia divaricata

Abstract

Keywords

ASJC Scopus subject areas

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