The metabolic syndrome, IGF-1, and insulin action

Yasumichi Arai, Toshio Kojima, Michiyo Takayama, Nobuyoshi Hirose

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are involved in the control of ageing and longevity in model organisms. Based on these studies, genes involved in the insulin/IGF-1 signaling pathway are believed to play a role in longevity throughout evolution and could also be important in determining human longevity. However, human studies have yielded conflicting and controversial results. In human, defects in insulin receptor signaling cause insulin resistance and diabetes, and IGF-1 deficiency is associated with an increased risk of cardiovascular disease and atherosclerosis. Interestingly, insulin sensitivity normally decreases during aging; however, centenarians were reported to maintain greatly increased insulin sensitivity and had a lower prevalence of the metabolic syndrome as compared to younger subjects. Additionally, a longitudinal study revealed that insulin-sensitizing hormones, including leptin and adiponectin, were significantly associated with the survival of centenarians, indicating that an efficient insulin response may influence human longevity.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalMolecular and Cellular Endocrinology
Issue number1
Publication statusPublished - 2009 Feb 5


  • Adipokines
  • Aging
  • Centenarian
  • Insulin/IGF-1 signaling
  • Longevity
  • Metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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